600 000+
publication views of all time
Our results and achievements
10 000+
subscribers across various platforms
400+
publications on evidence-based medicine
300+
channels have cited NIAEM
NIAEM's goal
NIAEM helps physicians register their study
01
Registry of prospective clinical studies
A Russian-language platform where Russian researchers can register their work without language barriers.
02
Guide to using the registry
Detailed instructions on navigating and using all the platform's features.
Manual on registering at ClinicalTrials.gov
A Russian-language guide with instructions on registering a study, managing the application, and examples of registering studies with various designs.
List of alternative foreign registries
A list of other international platforms for registering studies, with a description of each.
About the project
Publication bias in medicine and a plan to minimize the risks
Artur Rubenovich Navasardyan
Director of NIAEM, MD, PhD, cardiologist, senior lecturer at the Department of Clinical Epidemiology and Evidence-Based Medicine, National Medical Research Center for Therapy and Preventive Medicine (NMRC TPM)
Documents
According to international standards, before enrolling the first patient in any prospective clinical study, it is necessary to register the intention to conduct it, specifying the study design, criteria, and endpoints.
International Committee of Medical Journal Editors (ICMJE)
Establishes requirements for the registration of clinical studies as a mandatory condition for publication.
WHO document
Defines the minimum requirements for clinical trial registries.
Declaration of Helsinki
An ethical document governing the conduct of medical research and the need to register studies.
Committee on Publication Ethics (COPE)
Guidance on good practice for medical journal editors, including requirements for the registration of studies.
World Association of Medical Editors (WAME)
Recommendations of an international organization of editors on best practices in scientific publishing and the registration of studies.
Good Publication Practice guidelines (GPP)
For company-sponsored biomedical research.
Publishing a study
A negative result
also saves lives
Join the community of researchers. Find registered protocols and create new studies.
Questions
The tendency to publish primarily studies with statistically significant results. As a result, the body of accumulated data is skewed in favor of "positive" studies, while work with negative results often remains unpublished. This leads to the efficacy and safety profiles of any interventions being rated deliberately higher than they actually are. This tendency has a number of negative consequences for patients, the medical community, the healthcare system as a whole, and pharmaceutical companies. For the latter, publication bias also carries reputational and financial risks.
For this purpose, registration guidelines have been developed on the ClinicalTrials.gov website. A Russian-language registry of prospective studies, ClinicalStudy.RU, and a guide to using it have also been created. In addition, a list of other international registries has been prepared.
When enrolling in a research program, a patient signs an informed consent form stating that the results obtained will be used in the interest of other patients. The absence of a publication devalues the participation and the risks to which the patient was exposed as a result of taking part in the study.
Failing to publish results leads to the duplication of studies and the inefficient use of scientific resources. Entire teams spend time re-confirming a null hypothesis that has already been proven.
Any study involves significant financial costs: developing the protocol, maintaining documentation, the work of the research team, statistical analysis, and data processing. If the results of such studies are not published, the resources of the healthcare system are used irrationally and do not bring the expected benefit.
There are documents according to which any prospective clinical study must be registered in a registry of clinical studies and subsequently published. Registration is an integral part of the scientific process: it increases the transparency of studies, reduces the risk of data manipulation, and decreases publication bias.
Services
Evidence-based medicine in practice
Medical universities and departments
Scientific and methodological programs for developing research competencies.
Key areas
evidence-based medicine methodology
study design
critical appraisal of publications
biostatistics
manuscript preparation
Pharmaceutical companies
Expert support at every stage: from regulatory strategy to communicating the value of a drug.
Key areas
RWE/RWD
medical registries
regulatory strategies in the EAEU
medical marketing materials
webinars on Doclub.tv
Co-investigators and early-career researchers
Help with statistical processing, writing articles, and methodological support for studies.
Key areas
data analysis
consultations
data validation
protocol preparation
Clinics and medical centers
Tools for improving the quality of medical care and operational efficiency.
Key areas
optimization of patient routing
patient attrition analysis
improving treatment adherence
legal safety